Prognostic significance of E-cadherin expression in hepatocellular carcinoma: correlations with clinical features.

Autor:	Dobrescu AE; Discipline of Medical Semiology I, Department V - Internal Medicine I, Discipline of Morphopathology, Department II - Microscopic Morphology, 'Victor Babeş' University of Medicine and Pharmacy, Timişoara, Romania; norina.basa@yahoo.com, marioaracornianu@yahoo.com., Basa SN, Cornianu M, Lazăr DC, Suciu SC, Tudor A, Viţa OC, Tarţă-Marcu DC, Barna RA, Lazăr OF
Jazyk:	angličtina
Zdroj:	Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2019; Vol. 60 (4), pp. 1243-1251.
Abstrakt:	Background: Hepatocellular carcinoma (HCC) represents a major public health issue, being associated with high morbidity and mortality rates. Previous studies have demonstrated that reduction and∕or absence of E-cadherin expression is correlated with a potential for invasion and low survival rate in patients with HCC. Patients, Materials and Methods: We assessed the immunohistochemical expression of E-cadherin in 32 HCCs and peritumoral hepatic tissues using monoclonal anti-E-cadherin antibody (clone EP700Y), at 1:50 dilution, followed by incubation with Labeled Streptavidin-Biotin 2 (LSAB2) for 20 minutes, visualization of the reaction with 3,3'-Diaminobenzidine (DAB) and counterstaining with Mayer's Hematoxylin. Results: The results we obtained show: an aberrant E-cadherin expression more frequent in dysplastic nodules (p=0.285) and in 81.25% of HCC cases, as compared to normal hepatic tissue (p<0.001); the absence of a statistically significant relationship between E-cadherin expression and patients' gender (p=0.854), tumor localization (p=0.429), associated viral infection [hepatitis B virus (HBV) or hepatitis C virus (HCV)] (p=0.513) or tumor size (p=0.788); the rate of positive E-cadherin expression was significantly higher in tumors with capsular infiltration (75%) (p=0.017) and does not appear to be influenced by vascular invasion (62.5%) (p=0.411), the presence of satellite nodules (p=0.285) or the serum level of alpha-fetoprotein (α-FP) (p=0.787). Conclusions: Reduced E-cadherin expression indicates a poor prognosis for patients with HCC and can be considered a potential predictive marker for the prognosis of these patients.
Databáze:	MEDLINE
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