Differences between COVID-19 and suspected then confirmed SARS-CoV-2-negative pneumonia: A retrospective study from a single center.

Autor: Chen X; Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China., Yang Y; Department of Hematology, Chongqing Three Gorges Central Hospital, Chongqing, China., Huang M; Department of Internal Medicine, Baian Branch Hospital, Chongqing Three Gorges Central Hospital, Chongqing, China., Liu L; Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China., Zhang X; Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing, China., Xu J; Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China., Geng S; Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China., Han B; The Key Laboratory of Experimental Teratology, Ministry of Education and Department of Pathology, Shandong University, School of Basic Medical Sciences, Jinan, China., Xiao J; Department of Loemology, Chongqing Three Gorges Central Hospital, Chongqing, China., Wan Y; Department of General Medicine, Baian Branch Hospital, Chongqing Three Gorges Central Hospital, Chongqing, China.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2020 Sep; Vol. 92 (9), pp. 1572-1579. Date of Electronic Publication: 2020 Jun 12.
DOI: 10.1002/jmv.25810
Abstrakt: Coronavirus disease 2019 (COVID-19) broke out in Wuhan, Hubei, China in December 2019. Tens thousands of people have been infected with the disease. Our aim was to distinguish severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients from SARS-CoV-2-negative patients. We retrospectively compared the data of COVID-19 patients with those of suspected and confirmed SARS-CoV-2-negative patients (control patients). There were 78 COVID-19 patients and 26 control patients, whose median ages were significantly different (P = .001). The percentage of COVID-19 patients admitting exposure to Wuhan was obviously higher than that of control patients (X 2  = 29.130; P < .001). Fever and cough appeared more frequently in COVID-19 patients than in the control patients. The routine blood workup parameters of COVID-19 patients did not change much and their mean counts were in the normal range. There were 38.5% of control patients had higher procalcitonin (PCT) levels than 0.5 ng/mL, which was significantly higher than that percentage of COVID-19 patients (X 2  = 22.636; P < .05), and COVID-19 patients were also more likely to have decreased or normal urea and creatinine levels than control patients (X 2  = 24.930, 8.480; P < .05).Younger age, exposure to Wuhan, fever, cough, and slight changes in routine blood workup parameters, urea and creatinine were important features discriminating COVID-19 from control patients. Slightly increased, but far less than 0.5 ng/mL, PCT levels also differentiated COVID-19 patients from control patients.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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