Reference values for spirometry in Brazilian children.

Autor:	Jones MH; Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS - Porto Alegre (RS) Brasil., Vidal PCV; Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS - Porto Alegre (RS) Brasil., Lanza FC; Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG) Brasil., Silva DCFMF; Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG) Brasil., Pitrez PM; Hospital Moinhos de Vento, Porto Alegre (RS) Brasil., Olmedo APBF; Fundação Universidade Federal do Rio Grande - FURG - Rio Grande (RS) Brasil., Burity EF; Universidade Federal de Pernambuco - UFPE - Recife (PE) Brasil., Schisler KL; Hospital Ministro Costa Cavalcanti, Foz do Iguaçu (PR) Brasil., Pinto LA; Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS - Porto Alegre (RS) Brasil., Winck AD; Universidade de Caxias do Sul - UCS - Caxias do Sul (RS) Brasil., Souza ELS; Universidade Federal da Bahia - UFBA - Salvador (BA) Brasil., Oliveira AA; Hospital do Pulmão, Blumenau (SC) Brasil., Ribeiro MÂGO; Universidade Estadual de Campinas - UNICAMP - Campinas (SP) Brasil., Torres LAGMM; Universidade de São Paulo - USP - São Paulo (SP) Brasil., March MFBP; Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ) Brasil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2020 Mar 27; Vol. 46 (3), pp. e20190138. Date of Electronic Publication: 2020 Mar 27 (Print Publication: 2020).
DOI:	10.36416/1806-3756/e20190138
Abstrakt:	Objective: To generate reference values for spirometry in Brazilian children 3-12 years of age and to compare those values with the values employed in the equations currently in use in Brazil. Methods: This study involved healthy children, 3-12 years of age, recruited from 14 centers (primary data) and spirometry results from children with the same characteristics in six databases (secondary data). Reference equations by quantile regressions were generated after log transformation of the spirometric and anthropometric data. Skin color was classified as self-reported by the participants. To determine the suitability of the results obtained, they were compared with those predicted by the equations currently in use in Brazil. Results: We included 1,990 individuals from a total of 21 primary and secondary data sources. Of those, 1,059 (53%) were female. Equations for FEV1, FVC, the FEV1/FVC ratio, FEF between 25% and 75% of the FVC (FEF25-75%) and the FEF25-75%/FVC ratio were generated for white-, black-, and brown-skinned children. The logarithms for height and age, together with skin color, were the best predictors of FEV1 and FVC. The reference values obtained were significantly higher than those employed in the equations currently in use in Brazil, for predicted values, as well as for the lower limit of normality, particularly in children with self-reported black or brown skin. Conclusions: New spirometric equations were generated for Brazilian children 3-12 years of age, in the three skin-color categories defined. The equations currently in use in Brazil seem to underestimate the lung function of Brazilian children 3-12 years of age and should be replaced by the equations proposed in this study.
Databáze:	MEDLINE
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