Tumor suppressor and oncogenic role of long non-coding RNAs in cancer.
| Autor: | Guzel E; Department of Molecular Biology and Genetics, Health Sciences University, Hamidiye Institute of Health Sciences, Istanbul, Turkey., Okyay TM; Department of Medical Biochemistry, Health Sciences University, Hamidiye Faculty of Medicine, Istanbul, Turkey., Yalcinkaya B; TUBITAK National Metrology Institute (UME), Kocaeli, Turkey., Karacaoglu S; Health Sciences University, Hamidiye Faculty of Medicine, Istanbul, Turkey., Gocmen M; Health Sciences University, Hamidiye Faculty of Medicine, Istanbul, Turkey., Akcakuyu MH; Health Sciences University, Hamidiye Faculty of Medicine, Istanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Northern clinics of Istanbul [North Clin Istanb] 2019 Nov 22; Vol. 7 (1), pp. 81-86. Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2020). |
| DOI: | 10.14744/nci.2019.46873 |
| Abstrakt: | Non-coding RNAs are RNA molecules that are not translated into the protein, making up the vast majority of the human genome. Long non-coding RNAs (lncRNA) are in the RNA group that has longer than 200 nucleotides, and non-protein coding transcripts. In recent years, the potential has attracted considerable attention as new important biological regulators. LncRNAs play a critical role in regulating the activity and localization of proteins, processing the production of small RNAs, and processing other RNAs. They are also involved in cell differentiation, cell cycle, proliferation, apoptosis, migration and invasion by modulation of gene expression. Abnormal expression of LncRNAs has an important role in the function of oncogenes and tumor suppressor genes. Recently, there has been an increasing number of studies on the tumorigenic effects of specific lncRNAs in the initiation and progression of cancer. In this review, general information about lncRNAs is provided, including the biological importance of lncRNAs in cancer diseases and their potential development in therapeutic applications. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (Copyright: © 2020 by Istanbul Northern Anatolian Association of Public Hospitals.) |
| Databáze: | MEDLINE |
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