Can the development of atrial fibrillation in patients with ischemic heart failure with low ejection fraction be predicted?

Autor:	Alpsoy S; Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey., Erselcan K; Department Cardiology, Tekirdag State Hospital, Tekirdag, Turkey., Akyuz A; Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey., Gur DO; Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey., Topuz S; Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey., Topcu B; Department of Statistics, Namik Kemal University, Tekirdag, Turkey., Guler N; Department of Cardiology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey.
Jazyk:	angličtina
Zdroj:	Northern clinics of Istanbul [North Clin Istanb] 2019 Oct 08; Vol. 7 (1), pp. 18-24. Date of Electronic Publication: 2019 Oct 08 (Print Publication: 2020).
DOI:	10.14744/nci.2019.07078
Abstrakt:	Objective: Our aim is to determine the triggering factors of paroxysmal atrial fibrillation (PAF) in ischemic heart failure (HF) patients with low ejection fraction (EF). Methods: Sixty patients were included in this study. Echocardiography and 24-hours Holter monitoring were performed after measurement of serum NT-pro BNP concentration. The patients were classified into two groups concerning the occurrence of PAF on Holter recordings. Biochemical and echocardiographic parameters of patients with and without PAF were compared. Results: PAF was detected in 28 (46%) patients. Patients with PAF demonstrated higher NT-pro BNP levels, mitral and aortic regurgitation velocities, E/A, E/E', pulmonary capillary wedge pressure, pulmonary artery systolic pressure, left atrial volume and volume indices. NT-pro BNP was established as the predictor of PAF (OR=1.23, 95% CI: 1.08-1.42; p=0.001). ROC analysis showed an NT-pro BNP value of 2188 pg/mL as cut-off value with 68% sensitivity and 84% specificity [Area under the ROC curve (AUC)=0.826, CI 95%: 0.724-0.927; p<0.001]. Conclusion: The triggering factors for AF are increased intracardiac pressures, left atrial dilatation and increased wall tension. As an indicator of increased wall tension, elevated levels of NT-pro BNP predict the development of PAF. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (Copyright: © 2020 by Istanbul Northern Anatolian Association of Public Hospitals.)
Databáze:	MEDLINE
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