Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state.

Autor:	Liu H; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China., Du Y; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China., St-Pierre JP; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Bergholt MS; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Autefage H; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.; Division of Biomaterials, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Wang J; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China., Cai M; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China., Yang G; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China., Stevens MM; Department of Materials, Imperial College London, London SW7 2AZ, UK.; Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Zhang S; Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.; Advanced Biomaterials and Tissue Engineering Centre, Huazhong University of Science and Technology, Wuhan 430074, China.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2020 Mar 25; Vol. 6 (13), pp. eaay7608. Date of Electronic Publication: 2020 Mar 25 (Print Publication: 2020).
DOI:	10.1126/sciadv.aay7608
Abstrakt:	Cellular bioenergetics (CBE) plays a critical role in tissue regeneration. Physiologically, an enhanced metabolic state facilitates anabolic biosynthesis and mitosis to accelerate regeneration. However, the development of approaches to reprogram CBE, toward the treatment of substantial tissue injuries, has been limited thus far. Here, we show that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold compared to commercialized poly(lactic acid) and calcium phosphate ceramic scaffolds. This material was composed of energy-active units that can be released in a sustained degradation-mediated fashion once implanted. By establishing an intramitochondrial metabolic bypass, the internalized energy-active units significantly elevate mitochondrial membrane potential (ΔΨm) to supply increased bioenergetic levels and accelerate bone formation. The ready-to-use material developed here represents a highly efficient and easy-to-implement therapeutic approach toward tissue regeneration, with promise for bench-to-bedside translation. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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