B fibers are the best predictors of cardiac activity during Vagus nerve stimulation: Qing, vagal B fiber activation and cardiac effects.

Autor: Qing KY; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA.; 2Indiana University School of Medicine, Indianapolis, IN USA., Wasilczuk KM; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA., Ward MP; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA., Phillips EH; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA., Vlachos PP; 3Mechanical Engineering, Purdue University, West Lafayette, IN USA., Goergen CJ; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA., Irazoqui PP; 1Biomedical Engineering, Purdue University, West Lafayette, IN USA.
Jazyk: angličtina
Zdroj: Bioelectronic medicine [Bioelectron Med] 2018 Apr 20; Vol. 4, pp. 5. Date of Electronic Publication: 2018 Apr 20 (Print Publication: 2018).
DOI: 10.1186/s42234-018-0005-8
Abstrakt: Background: Vagus nerve stimulation (VNS) is a promising therapy for many neurologic and psychiatric conditions. However, determining stimulus parameters for individual patients is a major challenge. The traditional method of titrating stimulus intensity based on patient perception produces highly variable responses. This study explores using the vagal response to measure stimulation dose and predict physiological effect. Clinicians are investigating the use of VNS for heart failure management, and this work aims to correlate cardiac measures with vagal fiber activity.
Results: By recording vagal activity during VNS in rats and using regression analysis, we found that cardiac activity across all animals was best correlated to the activation of a specific vagal fiber group. With conduction velocities ranging from 5 to 10 m/s, these fibers are classified as B fibers (using the Erlanger-Gasser system) and correspond to vagal parasympathetic efferents.
Conclusions: B fiber activation can serve as a standardized, objective measure of stimulus dose across all subjects. Tracking fiber activation provides a more systematic way to study the effects of VNS and in the future, may lead to a more consistent method of therapy delivery.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s) 2018.)
Databáze: MEDLINE
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