A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes.

Autor:	Takai M; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Ishikawa M; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Maeda H; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Kubota A; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Iemitsu K; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Umezawa S; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Kawata T; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Takuma T; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Takeda H; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Tanaka K; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Machimura H; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Minagawa F; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Mokubo A; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Motomiya T; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Kanamori A; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan., Matsuba I; Diabetes Committee Study Group, Kanagawa Physicians Association, 1-3 Fujimichou, Nakaku, Yokohama, Kanagawa 231-0037, Japan.
Jazyk:	angličtina
Zdroj:	Journal of clinical medicine research [J Clin Med Res] 2020 Mar; Vol. 12 (3), pp. 200-208. Date of Electronic Publication: 2020 Mar 02.
DOI:	10.14740/jocmr4103
Abstrakt:	Background: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients. Methods: Using data collected from 630 patients in a multicenter study, we compared the amount of change in HbA1c after 1, 3, 6, 9, and 12 months of add-on administration of sitagliptin in insulin-treated patients divided into four groups based on the month when sitagliptin was started. Results: A significantly larger decrease in HbA1c at 6 months from baseline was observed in the group that started add-on sitagliptin in February to April than in the other three groups. However, the amount of change in HbA1c at 12 months did not differ among the groups. Conclusions: The consideration of seasonal variation enables more accurate evaluation of a drug's short-term effect on blood glucose control. Competing Interests: The authors declare no conflict of interest. (Copyright 2020, Takai et al.)
Databáze:	MEDLINE
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