Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans .

Autor:	Sakamoto T; Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan., Maebayashi K; Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan., Tsunoda Y; Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan., Imai H; Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Journal of clinical biochemistry and nutrition [J Clin Biochem Nutr] 2020 Mar; Vol. 66 (2), pp. 116-123. Date of Electronic Publication: 2020 Jan 31.
DOI:	10.3164/jcbn.19-51
Abstrakt:	Glutathione peroxidase 4 (GPx4) is a unique antioxidant enzyme that directly reduces the phospholipid hydroperoxides (PLOOH) generated in biomembranes using glutathione as the reductant. We have previously reported that the Caenorhabditis elegans gpx -quad mutant, which lacks all homologous genes of GPx4 has a reduced lifespan compared with the wild-type. However, the mechanisms underlying the lifespan reduction remain unclear. By monitoring the change in PLOOH production with age, we found that PLOOH was elevated in the gpx -quad mutants compared with the wild-type during the reproductive period. Administration of vitamin E not only reduced the PLOOH content but also prolonged the lifespan of the gpx -quad mutants. In contrast, vitamin C did not extend the lifespan of the gpx -quad mutants. Interestingly, we found that the inhibition of lipid peroxidation by vitamin E during 5 to 10 days after hatching is important to extend the lifespan of C. elegans . These results suggest that production of PLOOH during the reproductive period strongly influences the lifespan of C. elegans . Competing Interests: No potential conflicts of interest were disclosed. (Copyright © 2020 JCBNCopyright © 2020 JCBN.)
Databáze:	MEDLINE
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