Dietary exposure to mycotoxins in the French infant total diet study.

Autor: Vin K; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France. Electronic address: karine.vin@anses.fr., Rivière G; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Leconte S; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Cravedi JP; Toxalim (Research Centre in Food Toxicology), University of Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France., Fremy JM; Scientific Directorate Laboratory, French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Oswald IP; Toxalim (Research Centre in Food Toxicology), University of Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France., Roudot AC; University of Brest, LIEN, 6 avenue le Gorgeu, 29238, Brest cedex 3, France., Vasseur P; University of Lorraine, CNRS, UMR7360, Metz, France., Jean J; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Hulin M; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Sirot V; Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Jun; Vol. 140, pp. 111301. Date of Electronic Publication: 2020 Mar 27.
DOI: 10.1016/j.fct.2020.111301
Abstrakt: The present study evaluated the exposure of children aged from one to 36 months to seven groups of mycotoxins, in the context of the infant French Total Diet Study (iTDS). Exposure was then compared to the health-based guidance values (HBGVs) for each mycotoxin. The value of the 90th percentile of exposure to nivalenol, patulin, fumonisins and zearalenone was less than 40% of the HBGV considered relevant for children. On the other hand, a risk could not be excluded for ochratoxin A and aflatoxins as exposure was close to the HBGV for ochratoxin A and the margin of exposure was much lower than the critical margin of 10,000 for aflatoxins. The HBGVs for toxins T2 and HT2, and for deoxynivalenol (DON) and its acetylated compounds were exceeded. Five percent to 10% of the children aged 5-12 months exceeded the HBGV considering the lower bound hypothesis for toxins T2 and HT2 and 7.5%-27% of the children aged 5 months and above exceeded the HBGV for DON. Consequently, the exposure of young children raises safety concerns for T2/HT2 and DON. Efforts should therefore be pursued to decrease their exposure to these molecules.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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