Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications.

Autor: Del Carpio E; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.; Unidad de Química Medicinal, Facultad de Farmacia, Escuela 'Dr. Jesús María Bianco', Universidad Central de Venezuela, Venezuela., Hernández L; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.; Escuela de Quimica, Facultad de Ciencias, Universidad Central de Venezuela, Venezuela., Ciangherotti C; Laboratorio de Neuropéptidos, Facultad de Farmacia, Escuela 'Dr. Jesús María Bianco', Universidad Central de Venezuela, Venezuela.; Laboratorio de Bioquímica, Facultad de Farmacia, Escuela 'Dr. Jesús María Bianco', Universidad Central de Venezuela, Venezuela., Villalobos Coa V; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela., Jiménez L; Facultad de ingeniería Química, Universidad de Carabobo, Venezuela., Lubes V; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela., Lubes G; Laboratorio de Equilibrios en Solución, Universidad Simón Bolívar (USB), Apartado 89000, Caracas 1080 A, Venezuela.
Jazyk: angličtina
Zdroj: Coordination chemistry reviews [Coord Chem Rev] 2018 Oct 01; Vol. 372, pp. 117-140. Date of Electronic Publication: 2018 Jun 21.
DOI: 10.1016/j.ccr.2018.06.002
Abstrakt: In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.
(© 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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