Photon-counting, energy-resolving and super-resolution phase contrast X-ray imaging using an integrating detector.

Autor: O'Connell DW, Morgan KS, Ruben G, Schaff F, Croton LCP, Buckley GA, Paganin DM, Uesugi K, Kitchen MJ
Jazyk: angličtina
Zdroj: Optics express [Opt Express] 2020 Mar 02; Vol. 28 (5), pp. 7080-7094.
DOI: 10.1364/OE.384928
Abstrakt: This work demonstrates the use of a scientific-CMOS (sCMOS) energy-integrating detector as a photon-counting detector, thereby eliminating dark current and read-out noise issues, that simultaneously provides both energy resolution and sub-pixel spatial resolution for X-ray imaging. These capabilities are obtained by analyzing visible light photon clouds that result when X-ray photons produce fluorescence from a scintillator in front of the visible light sensor. Using low-fluence monochromatic X-ray projections to avoid overlapping photon clouds, the centroid of individual X-ray photon interactions was identified. This enabled a tripling of the spatial resolution of the detector to 6.71 ± 0.04 µm. By calculating the total charge deposited by this interaction, an energy resolution of 61.2 ± 0.1% at 17 keV was obtained. When combined with propagation-based phase contrast imaging and phase retrieval, a signal-to-noise ratio of up to 15 ± 3 was achieved for an X-ray fluence of less than 3 photons/mm 2 .
Databáze: MEDLINE