| Autor: |
Borges GA; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.; Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil., Webber LP; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA., M Marques AE; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.; Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil., Guerra EN; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.; Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil., Castilho RM; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.; The Michigan Medicine Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Squarize CH; Laboratory of Epithelial Biology, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.; The Michigan Medicine Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. |
| Abstrakt: |
Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog (PTEN) inhibitors and their effects on tissue repair and regeneration. In conditions associated with neurodegeneration, tissue injury and ischemia, the PTEN-regulated PI3K/AKT signaling pathway is activated. The use of PTEN inhibitors resulted in better tissue response by reducing the healing time and lesion sizes or inducing neuronal regeneration. Notably, all studies included in this systematic review indicated that pharmacological inhibition of PTEN enhanced the repair process of the eye, lung, muscle and nervous system. |
