Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging.

Autor: Spurlock B; Department of Genetics, University of Alabama at Birmingham, Birmingham, USA., Tullet J; School of Biosciences, University of Kent, Canterbury, Kent, UK., Hartman JL 4th; Department of Genetics, University of Alabama at Birmingham, Birmingham, USA., Mitra K; Department of Genetics, University of Alabama at Birmingham, Birmingham, USA. Electronic address: kasturi@uab.edu.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2020 Jul 01; Vol. 135, pp. 110919. Date of Electronic Publication: 2020 Mar 24.
DOI: 10.1016/j.exger.2020.110919
Abstrakt: Declining mitochondrial function and homeostasis is a hallmark of aging. It is appreciated that the role of mitochondria is much more complex than generating reactive oxygen species to cause aging-related tissue damage. More recent literature describes that the ability of mitochondria to undergo fission or fusion events with each other impacts aging processes. A dynamic balance of mitochondrial fission and fusion events is required to sustain critical cellular functions including cell cycle. Specifically, cell cycle regulators modulate molecular activities of the mitochondrial fission (and fusion) machinery towards regulating cell cycle progression. In this review, we discus literature leading to our understanding on how shifts in the dynamic balance of mitochondrial fission and fusion can modulate progression through, exit from, and re-entry to the cell cycle or in undergoing senescence. Importantly, core regulators of mitochondrial fission or fusion are emerging as crucial stem cell regulators. We discuss the implication of such regulation in stem cells in the context of aging, given that aberrations in adult stem cells promote aging. We also propose a few hypotheses that may provide direction for further understanding about the roles of mitochondrial fission-fusion dynamics in aging biology.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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