Interval timing deficits and their neurobiological correlates in aging mice.

Autor: Gür E; Timing and Decision-Making Laboratory, Department of Psychology, Koç University, Istanbul, Turkey; Koç University Research Center for Translational Medicine, Istanbul, Turkey., Duyan YA; Timing and Decision-Making Laboratory, Department of Psychology, Koç University, Istanbul, Turkey; Koç University Research Center for Translational Medicine, Istanbul, Turkey., Arkan S; Timing and Decision-Making Laboratory, Department of Psychology, Koç University, Istanbul, Turkey; Koç University Research Center for Translational Medicine, Istanbul, Turkey; Kocaeli University, Physiology Department, Umuttepe Campus, Kocaeli, Turkey., Karson A; Kocaeli University, Physiology Department, Umuttepe Campus, Kocaeli, Turkey., Balcı F; Timing and Decision-Making Laboratory, Department of Psychology, Koç University, Istanbul, Turkey; Koç University Research Center for Translational Medicine, Istanbul, Turkey. Electronic address: fbalci@ku.edu.tr.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2020 Jun; Vol. 90, pp. 33-42. Date of Electronic Publication: 2020 Mar 04.
DOI: 10.1016/j.neurobiolaging.2020.02.021
Abstrakt: Age-related neurobiological and cognitive alterations suggest that interval timing (as a related function) is also altered in aging, which can, in turn, disrupt timing-dependent functions. We investigated alterations in interval timing with aging and accompanying neurobiological changes. We tested 4-6, 10-12, and 18-20 month-old mice on the dual peak interval procedure. Results revealed a specific deficit in the termination of timed responses (stop-times). The decision processes contributed more to timing variability (vs. clock/memory process) in the aged mice. We observed age-dependent reductions in the number of dopaminergic neurons in the VTA and SNc, cholinergic neurons in the medial septum/diagonal band (MS/DB) complex, and density of dopaminergic axon terminals in the DLS/DMS. Negative correlations were found between the number of dopaminergic neurons in the VTA and stop times, and the number of cholinergic neurons in MS/DB complex and the acquisition of stop times. Our results point at age-dependent changes in the decisional components of interval timing and the role of dopaminergic and cholinergic functions in these behavioral alterations.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: