Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses.

Autor:	Park S; Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Graduate School of Urban Public Health, University of Seoul, Seoul, Republic of Korea., Nixon CE; Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Miller O; Department of Global Health, DePauw University, Greencastle, Indiana, USA., Choi NK; Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea., Kurtis JD; Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Friedman JF; Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Michelow IC; Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2020 Jul 23; Vol. 222 (4), pp. 538-550.
DOI:	10.1093/infdis/jiaa139
Abstrakt:	Background: Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy. Methods: We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Library for eligible prospective studies. The primary predictor was malaria during pregnancy defined as placental malaria, parasitemia, clinical malaria, or pregnancy-associated malaria. Primary outcomes were parasitemia or clinically defined malaria of young children. We performed meta-analyses to pool adjusted risk estimates using a random-effects model. Results: Nineteen of 2053 eligible studies met inclusion criteria for the systemic review. Eleven of these studies were quantitative and were included in the meta-analyses. The pooled adjusted odds ratio (aOR) or adjusted hazard ratio (aHR) of malaria during pregnancy for detection of parasitemia in young children were 1.94 (95% confidence interval [CI], 0.93-4.07; P = .08) and 1.46 (95% CI, 1.07-2.00; P < .001), respectively. The pooled aOR or aHR for clinically defined malaria in young children were 2.82 (95% CI, 1.82-4.38; P < .001) and 1.31 (95% CI, 0.96-1.79; P = .09), respectively. Conclusions: Our results confirmed that malaria during pregnancy significantly increased the overall risk of malaria in young children via indeterminate mechanisms and emphasize the urgent need to implement safe and highly effective strategies to prevent malaria during pregnancy. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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