Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model.

Autor: Huang XH; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Qian MB; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China.; WHO Collaborating Centre for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China., Zhu GH; Department of Mathematics and Computing Science, Guilin University of Electronic Technology, Guilin, Guangxi, People's Republic of China., Fang YY; Institute of Parasitic Diseases, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, People's Republic of China., Hao YT; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.; Sun Yat-sen Global Health Institute, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China., Lai YS; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.; Sun Yat-sen Global Health Institute, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Mar 27; Vol. 14 (3), pp. e0008152. Date of Electronic Publication: 2020 Mar 27 (Print Publication: 2020).
DOI: 10.1371/journal.pntd.0008152
Abstrakt: Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strategies on morbidity control of the disease. We developed a multi-group transmission model to describe the dynamics of C. sinensis transmission among different groups of people with different raw-fish-consumption behaviors, based on which, a full model with interventions was proposed and three common control measures (i.e., preventive chemotherapy, information, education, and communication (IEC) and environmental modification) and their possible combinations were considered. Under a typical setting of C. sinensis transmission, we simulated interventions according to different strategies and with a series of values of intervention parameters. We found that combinations of measures were much beneficial than those singly applied; higher coverages of measures had better effects; and strategies targeted on whole population performed better than that on at-risk population with raw-fish-consumption behaviors. The strategy recommended by the government of Guangdong Province, China shows good and sustainable effects, under which, the infection control (with human prevalence <5%) could be achieved within 7.84 years (95% CI: 5.78-12.16 years) in our study setting (with original observed prevalence 33.67%). Several sustainable strategies were provided, which could lead to infection control within 10 years. This study makes the effort to quantitatively assess the long-term effects of possible control strategies against C. sinensis infection under a typical transmission setting, with application of a multi-group dynamic transmission model. The proposed model is easily facilitated with other transmission settings and the simulation outputs provide useful information to support the decision-making of control strategies on clonorchiasis.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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