Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease.

Autor: Tashbayev B; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway. behzodt@odont.uio.no., Utheim TP; The Norwegian Dry Eye Clinic, 0366, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450, Oslo, Norway.; Department of Ophthalmology, Oslo University Hospital, 0450, Oslo, Norway.; Institute of Oral Biology, Faculty of Dentistry, University of Oslo, 0318, Oslo, Norway.; Department of Ophthalmology, Vestre Viken Hospital Trust, 3019, Drammen, Norway.; Department of Ophthalmology, Sørlandet Hospital Arendal, 4604, Arendal, Norway.; National Centre for Optics, Vision and Eye Care, Faculty of Health Sciences, University of South Eastern Norway, 3603, Kongsberg, Norway., Utheim ØA; The Norwegian Dry Eye Clinic, 0366, Oslo, Norway., Ræder S; The Norwegian Dry Eye Clinic, 0366, Oslo, Norway., Jensen JL; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway., Yazdani M; The Norwegian Dry Eye Clinic, 0366, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450, Oslo, Norway., Lagali N; Department of Ophthalmology, Sørlandet Hospital Arendal, 4604, Arendal, Norway.; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden., Vitelli V; Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway., Dartt DA; Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Chen X; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Department of Ophthalmology, Vestre Viken Hospital Trust, 3019, Drammen, Norway.; Department of Ophthalmology, Sørlandet Hospital Arendal, 4604, Arendal, Norway.; National Centre for Optics, Vision and Eye Care, Faculty of Health Sciences, University of South Eastern Norway, 3603, Kongsberg, Norway.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Mar 26; Vol. 10 (1), pp. 5542. Date of Electronic Publication: 2020 Mar 26.
DOI: 10.1038/s41598-020-62583-x
Abstrakt: The prevalence of dry eye disease is high worldwide and poses a great burden on patients' daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is believed to be the disease marker and thus measuring it provides useful information. In this study we investigated utility of tear osmolarity measured with TearLab osmometer, along with other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear film break-up time, Ocular Protection Index, Ocular Surface Staining, Schirmer I test, Meibomian gland functionality in 757 patients (1514 eyes) with dry eye disease and 29 healthy controls (58 eyes). Statistical differences between the patient group and the control group were observed for all the tests apart from tear osmolarity, regardless of cut-off value (>308 mOsm/L, >316 mOsm/L, and inter-eye difference >8 mOsm/L). Moreover, in the receiver operating characteristics curve analyses tear osmolarity measurement could not discriminate dry eye disease pathological scores. Therefore, our study suggests that tear osmolarity measured with TearLab osmometer cannot be used as a key indicator of DED.
Databáze: MEDLINE
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