Autologous Transplantation of Adipose-Derived Stem Cells to Treat Acute Spinal Cord Injury: Evaluation of Clinical Signs, Mental Signs, and Quality of Life.

Autor:	Tien NLB; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi, Vietnam., Hoa ND; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi, Vietnam., Thanh VV; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi, Vietnam., Thach NV; Department of Surgery, Hanoi Medical University, Hanoi, Vietnam., Ngoc VTN; School of Odonto Stomatology, Hanoi Medical University, Hanoi, Vietnam., Dinh TC; Institute for Research and Development, Duy Tan University, Danang, Vietnam., Phuong TNT; Department of Animal Science, College of Agriculture and Life Science, Chonnam National University, Gwangju 61186, Korea., Toi PL; Health Strategy and Policy Institute, Ministry of Health, Hanoi, Vietnam., Chu DT; Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2019 Dec 20; Vol. 7 (24), pp. 4399-4405. Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019).
DOI:	10.3889/oamjms.2019.843
Abstrakt:	Backgroud: Spinal cord injury (SCI) is damage that can cause a temporary or permanent change in spinal cord functions. Aim: This work evaluates clinical signs, mental signs, and quality of life (QoL) after autologous adipose-derived stem cells (ADSCs) transplantation to treat acute spinal cord injury (SCI). Methods: In this study, 47 SCI patients were recruited and divided into two groups: intervention and control. ADSCs were isolated and cultured under the cell culture quality control procedure. All patients in both groups underwent neurosurgery with or without ADSC transplantation. The recovery regarding neurological muscle, QoL, neurogenic bladder, and mental improvement was assessed after transplantation. Results: All patients had improved in terms of motor function, bladder function, and daily living. No patients reported any side effect. MRI imaging showed significant changes in the lesion length of the spinal canal and the thickening of the spinal cord. Mental improvement was highest at six months after transplantation and lowest at one month after transplantation. The proportion of patients whose quality of life improved after treatment was 100%, while 80% of patients were satisfied with treatment outcomes. Conclusions: Thus, our data suggested that ADSCs transplantation was safe and effective for the treatment of SCI patients. Neurological muscle and neurogenic bladder were improved significantly after transplantation. (Copyright: © 2019 Nguyen Le Bao Tien, Nguyen Dinh Hoa, Vo Van Thanh, Nguyen Van Thach, Vo Truong Nhu Ngoc, Thien Chu Dinh, Thuy Nguyen Thi Phuong, Phung Lam Toi, Dinh Toi Chu.)
Databáze:	MEDLINE
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