Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses.

Autor: Kazakova OB; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Medvedeva NI; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Baikova IP; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Tolstikov GA; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Lopatina TV; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Yunusov MS; 1Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia., Zaprutko L; 2Organic Chemistry Department, Poznan University of Medical Sciences, Poznan, Poland.
Jazyk: angličtina
Zdroj: Russian journal of bioorganic chemistry [Russ J Bioorg Chem] 2010; Vol. 36 (6), pp. 771-778. Date of Electronic Publication: 2010 Nov 19.
DOI: 10.1134/S1068162010060142
Abstrakt: The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28- ortho -Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.
(© Pleiades Publishing, Ltd. 2010.)
Databáze: MEDLINE
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