| Autor: |
Maznychenko AV; Department of Movement Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine, maznychenko@biph.kiev.ua.; Department of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland., Mankivska OP; Department of Cytology, Bogomoletz Institute of Physiology, Kyiv, Ukraine., Sokolowska Vereshchaka IV; Department of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland., Kopyak BS; Department of Blood Circulation, Bogomoletz Institute of Physiology, Kyiv, Ukraine., Tomiak T; Department of Physical Education, Gdansk University of Physical Education and Sport, Gdańsk, Poland., Bulgakova NV; Department of Movement Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine., Gonchar OO; Department of Hypoxic States Investigation, Bogomoletz Institute of Physiology, Kyiv, Ukraine., Prylutskyy YI; Taras Shevchenko National University of Kyiv, ESC 'Institute of Biology and Medicine', Kyiv, Ukraine., Ritter U; Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, Germany., Mishchenko IV; Lesya Ukrainka Eastern European National University, Lutsk, Ukraine., Kostyukov AI; Department of Movement Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine. |
| Abstrakt: |
The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long‑lasting (persisting for one hour) rotational movements in non‑anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotational movements in hemiparkinsonic animals were initiated by the intraperitoneal administration of the dopamine receptor agonist apomorphine. It was shown that a preliminary injection of C60FAS (a substance with powerful antioxidant properties) in hemiparkinsonic rats induced distinct changes in animal motor behavior. It was revealed that fullerene‑pretreated animals, in comparison with non‑pretreated or vehicle‑pretreated rats, rotated for 1 h at an approximately identical speed until the end of the experiment, whereas the rotation speed of control rats gradually decreased to 20-30% of the initial value. One can assume that the observed changes in the movement dynamics of the hemiparkinsonic rats after C60FAS pretreatment presumably can be induced by the influence of C60FAS on the dopaminergic system, although the isolated potentiation of the action of apomorphine C60FAS cannot be excluded. Nevertheless, earlier data on the action of C60FAS on muscle dynamics has suggested that C60FAS can activate a protective action of the antioxidant system in response to long‑lasting muscular activity and that the antioxidant system in turn may directly decrease fatigue‑relate d changes during long‑lasting muscular activity. |
