[Patterns of brain functional connectivity in frontal and temporal lobe epilepsies].

Autor:	Samotaeva IS; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Teplyshova AM; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Rider FK; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Solomatin YV; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Luzin RV; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Lebedeva NN; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia; Research and Clinical Center for Neuropsychiatry, Moscow, Russia., Guekht AB; Research and Clinical Center for Neuropsychiatry, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2019; Vol. 119 (11. Vyp. 2), pp. 11-15.
DOI:	10.17116/jnevro201911911211
Abstrakt:	Aim: To examine alterations of functional connectivity (FC) of the brain in patients with frontal and temporal lobe epilepsies. Material and Methods: Forty-three patients, aged 18-55 years, including 32 with temporal lobe epilepsy (TLE) and 11 with frontal lobe epilepsy (FLE), and 32 age/gender-matched healthy controls (HC) underwent structural and functional MRI on 1,5 T scanner. Imaging data were further analysed for functional connectivity characteristics by seed-based and ICA analyses. Results: Most prominent in the TLE group, was a decrease in FC of insula and peri-insular cortical regions compared to HC. These alterations of FC in left-side TLE were significant on the left. An increase of FC between dorsal part of attention resting network and regions of temporal and parietal cortices characterized right-side TLE. In addition, TLE group had decreased FC between anterior cingulate and basal ganglia. All the significant alterations of FC in FLE related to increased FC in patients compared to HC. FC of temporal regions was altered to a greater extent. Conclusion: Localization and lateralization of seizure focus determines the alterations of brain FC in patients with focal epilepsy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu