The role of melanins in melanotic fungi for pathogenesis and environmental survival.

Autor: Eisenman HC; Department of Natural Sciences, Baruch College of The City University of New York, 17 Lexington Avenue, New York, NY, 10010, USA. helene.eisenman@baruch.cuny.edu.; Graduate Center of the City University of New York, PhD Program in Biology, The City University of New York, 365 Fifth Avenue, New York, NY, 10016, USA. helene.eisenman@baruch.cuny.edu., Greer EM; Department of Natural Sciences, Baruch College of The City University of New York, 17 Lexington Avenue, New York, NY, 10010, USA., McGrail CW; Department of Natural Sciences, Baruch College of The City University of New York, 17 Lexington Avenue, New York, NY, 10010, USA.
Jazyk: angličtina
Zdroj: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2020 May; Vol. 104 (10), pp. 4247-4257. Date of Electronic Publication: 2020 Mar 23.
DOI: 10.1007/s00253-020-10532-z
Abstrakt: Melanins provide fungi protection from environmental stressors, support their ecological roles, and can confer virulence in pathogens. While the function, structure, and synthesis of melanins in fungi are not fully understood, they have been shown to have varied roles. Recent research has revealed a wide range of functions, from radiation resistance to increasing virulence, shedding light on fungal diversity. Understanding fungal melanins can provide useful information, from harnessing the properties of these various melanins to targeting fungal infections.Key Points• Melanotic fungi are widespread in nature. • Melanin functions to protect fungi in the environment from a range of stresses. • Melanin contributes to pathogenesis and drug resistance of pathogenic fungi.
Databáze: MEDLINE
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