Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: A double-blind randomized clinical trial.

Autor: de Souza LC; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: lidiane.csouza@yahoo.com.br., Rodrigues NS; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: nara.sousa.rodrigues@gmail.com., Cunha DA; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: araujo.diana@gmail.com., Feitosa VP; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil; Paulo Picanço School of Dentistry, Fortaleza, Ceará, Brazil. Electronic address: victorpfeitosa@hotmail.com., Santiago SL; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: sergiosantiago@yahoo.com., Reis A; School of Dentistry, Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil. Electronic address: reis_ale@hotmail.com., Loguercio AD; School of Dentistry, Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil. Electronic address: aloguercio@hotmail.com., Perdigão J; Department of Restorative Sciences, University of Minnesota, Minneapolis, MN, USA. Electronic address: perdi001@umn.edu., Saboia VPA; Postgraduate Program of Dentistry - Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: vpsaboia@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2020 May; Vol. 96, pp. 103325. Date of Electronic Publication: 2020 Mar 20.
DOI: 10.1016/j.jdent.2020.103325
Abstrakt: Objectives: This double-blind randomized clinical trial evaluated the influence of pre-treatment with proanthocyanidins (PA) from grape seed extract on the clinical behavior of a simplified etch-and-rinse adhesive placed in non-carious cervical lesions (NCCLs) over 6- and 24-months.
Materials and Methods: A total of 135 restorations were randomly inserted in 45 subjects. The NCCLs were etched with 37 % phosphoric acid for 15 s and distributed into 3 groups: Control (PA0) - adhesive ExciTE F applied as per the manufacturer's recommendations; PA2 and PA5 groups - 2 wt% and 5 wt% PA solution, respectively, were applied for 60 s and washed for 30 s prior to application of the adhesive. The resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline, 6 months (6 m) and 24 months (24 m) using both the FDI and USPHS criteria. Statistical analyses were carried out using Friedman repeated-measures analysis of variance by rank and the Wilcoxon test (α = 0.05).
Results: The retention rates were 98 % (PA0), 98 % (PA2) and 83 % (PA5) after 6 m and 93 % (PA0), 89 % (PA2) and 70 % (PA5) after 24 m. Only PA5 resulted in a significant lower retention rate at 6 m and at 24 m compared with that of baseline (p = 0.03). All groups resulted in a significantly worse marginal adaptation and marginal staining for the FDI criteria when the baseline vs. the 24 m recall data were compared. These differences were considered clinically acceptable under the FDI criteria.
Conclusions: The application of PA as a primer did not result in clinical advantages after 24 m of clinical service, regardless of the concentration used.
Clinical Relevance: It has been reported that PA, a collagen crosslinking agent, increases the durability of the dentin-resin interface. However, no effects were found clinically after 24 months.
Competing Interests: Declaration of Competing Interest None of the authors of the manuscript “Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions: a double-blind randomized clinical trial” have any conflict of interest to declare.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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