Phaeohyphomycosis: Cytomorphologic Evaluation in Eleven Cases.
| Autor: | Kundu R; Government Medical College and Hospital, Chandigarh, India, reetukundu@gmail.com., Handa U; Government Medical College and Hospital, Chandigarh, India., Punia RS; Government Medical College and Hospital, Chandigarh, India., Singla N; Government Medical College and Hospital, Chandigarh, India., Chander J; Government Medical College and Hospital, Chandigarh, India., Attri AK; Government Medical College and Hospital, Chandigarh, India. |
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| Jazyk: | angličtina |
| Zdroj: | Acta cytologica [Acta Cytol] 2020; Vol. 64 (5), pp. 406-412. Date of Electronic Publication: 2020 Mar 23. |
| DOI: | 10.1159/000506432 |
| Abstrakt: | Objective: Phaeohyphomycosis caused by phaeoid fungi is a type of mycosis emerging worldwide which causes a wide variety of clinical manifestations. Study Design: A retrospective analysis of 11 cases diagnosed with fungal inflammation on cytology over a period of 6 years (2013-2018) was done along with culture/histopathologic confirmation. Results: Of the total of 11 cases, 9 cases presented with subcutaneous swellings and 1 case each with brain and lung lesions. The age range was 30-83 years (mean: 53.6); 8 patients were male and 3 were female. Cytologic smears showed fungal profiles with septate tortuous hyphae, as well as swollen and narrow, yeast-like swellings with an irregular breadth of the hyphae in all cases. The fungal profiles were visualized on a Masson-Fontana stain. The background showed inflammatory cells, giant cells, and necrosis in variable proportions. Five cases were diagnosed as phaeohyphomycosis on cytology, whereas 3 cases were misdiagnosed as aspergillus and 2 as candida. In 1 case, typing of the fungus was not done. Histopathology was available in 5 cases, and in all these a diagnosis of phaeohyphomycosis was reached. Ten of the 11 cases had confirmation on fungal culture. Conclusions: Phaeoid fungi are rarely seen in routine cytologic practice. Careful evaluation of cytologic smears and an awareness of the characteristic morphologic features of phaeohyphomycosis are helpful in arriving at a correct diagnosis. Fine needle aspiration cytology provides a rapid diagnosis, enabling prompt therapy. (© 2020 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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