Clinical manifestation of norovirus infection in children aged less than five years old admitted with acute diarrhea in Surabaya, Indonesia: a cross-sectional study.

Autor:	Fardah Athiyyah A; Department of Child Health, Faculty of Medicine, Airlangga University, Moestopo Street 6-8, Surabaya, 60286, Indonesia.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia., Shigemura K; Department of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science, 7-10-2 Tomogaoka Suma-ku, Kobe, 654-0142, Japan.; Department of Infection Control and Prevention, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan., Kitagawa K; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science, 7-10-2 Tomogaoka Suma-ku, Kobe, 654-0142, Japan.; Department of Advanced Medical Science, Kobe University Graduate School of Science, Technology and Innovation, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan., Agustina N; Department of Child Health, Faculty of Medicine, Airlangga University, Moestopo Street 6-8, Surabaya, 60286, Indonesia.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia., Darma A; Department of Child Health, Faculty of Medicine, Airlangga University, Moestopo Street 6-8, Surabaya, 60286, Indonesia.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia., Ranuh R; Department of Child Health, Faculty of Medicine, Airlangga University, Moestopo Street 6-8, Surabaya, 60286, Indonesia.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia., Raharjo D; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia.; Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia., Shirakawa T; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia.; Department of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science, 7-10-2 Tomogaoka Suma-ku, Kobe, 654-0142, Japan.; Department of Advanced Medical Science, Kobe University Graduate School of Science, Technology and Innovation, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.; Center for Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan., Fujisawa M; Department of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan., Marto Sudarmo S; Department of Child Health, Faculty of Medicine, Airlangga University, Moestopo Street 6-8, Surabaya, 60286, Indonesia.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya, 60115, Indonesia.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2019 Dec 20; Vol. 8, pp. 2130. Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019).
DOI:	10.12688/f1000research.21069.3
Abstrakt:	Background: The objective of this study was to investigate the clinical manifestation of norovirus infection between norovirus genogroup and severity of acute diarrhea in pediatric patients at the Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: This cross-sectional study involved 31 participants aged 1-60 months admitted to the hospital with acute diarrhea from April 2012 to March 2013. Norovirus genogroups (GI and II) were identified from patient stool using reverse transcription polymerase chain reaction (RT-PCR). Severity was measured using the Ruuska and Vesikari scoring system. Results: In total, 94 stool samples were obtained, of which 31 (19%) were norovirus positive. Norovirus GI was found in one sample with mild diarrhea. Norovirus GII was found in 30 samples (96.8%); one sample with mild diarrhea (3.3%), 20 samples with moderate diarrhea (66.7%), and nine samples with severe diarrhea (30%). Conclusion: Norovirus GII was the most prevalent cause of acute diarrhea and 30% of the cases manifested as severe diarrhea. Competing Interests: No competing interests were disclosed. (Copyright: © 2020 Fardah Athiyyah A et al.)
Databáze:	MEDLINE
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