Potential diagnostic and therapeutic value of circular RNAs in cardiovascular diseases.

Autor: Sun JY; The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China., Shi Y; Department of Emergency, The Affiliated Huai'an Hospital of Xuzhou Medical College and The Second People's Hospital of Huai'an, Huai'an, China., Cai XY; Department of Cardiology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China. Electronic address: cxyandcxy213@163.com., Liu J; Department of Critical Care Medicine, School of Medicine, Ruijin Hospital North, Shanghai Jiaotong University Shanghai, China. Electronic address: catherine015@163.com.
Jazyk: angličtina
Zdroj: Cellular signalling [Cell Signal] 2020 Jul; Vol. 71, pp. 109604. Date of Electronic Publication: 2020 Mar 19.
DOI: 10.1016/j.cellsig.2020.109604
Abstrakt: Cardiovascular diseases (CVDs) have imposed a massive health and financial burden worldwide with high mortality and morbidity. However, the diagnostic value of current biomarkers might be impaired by a wide variety of noncardiac causes. Moreover, cardiovascular outcomes, survival, and prognosis of patients with CVDs remain poor despite advances in treatment. Therefore, novel diagnostic and therapeutic strategies are urgently required for timely identification of possible heart diseases in the early stage, which might effectively contribute to reducing the CVDs-caused morbidity and mortality. Circular RNA (circRNA) was initially identified as aberrant byproducts or abnormally spliced transcripts. However, with advances in bioinformatics and high-throughput sequencing technology, circRNAs has become an essential topic on a wide range of biological functions and emerged as novel players in diagnostic and therapeutic strategies for CVDs. In this article, we briefly introduce the biogenesis and functions of circRNAs. Moreover, we describe the roles of circRNAs in multiple CVDs, including atherosclerosis, coronary artery disease, myocardial infarction, as well as cardiomyopathy. In addition, we provide an overview on the current challenges and directions for further application.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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