Impact of liraglutide on microcirculation in experimental diabetic cardiomyopathy.

Autor: Abdelrazik Soliman NG; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt. Electronic address: nehadgamal@mans.edu.eg., Abdel-Hamid AAM; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt; Department of Anatomy, Taibah College of Medicine, Taibah University, Almadina Almonawara, Saudi Arabia. Electronic address: profahmadpasha@mans.edu.eg., El-Hawwary AA; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt., Ellakkany A; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.
Jazyk: angličtina
Zdroj: Acta histochemica [Acta Histochem] 2020 Apr; Vol. 122 (3), pp. 151533. Date of Electronic Publication: 2020 Mar 17.
DOI: 10.1016/j.acthis.2020.151533
Abstrakt: Liraglutide is a new therapy used in diabetes and its effect on diabetic complications particularly cardiovascular ones is still under investigated. In our research, we tried to study the effect of liraglutide on experimental diabetic cardiomyopathy (DCM) induced by streptozotocin. We found that liraglutide nearly preserved normal myocardiac structure and significantly protected against myocardiac inflammation and fibrosis that was found in DCM group, p < 0.05. It also increased the density of coronary arteriolar vasculature markedly indicated by significant increase in α SMA (p < 0.05) compared to both DCM and non-diabetic (ND) groups. Moreover, liraglutide decreased TNFα and increased VEGF proteins expression (P < 0.05) compared to DCM group. Conclusion, liraglutide may have a very important role in protecting against experimentally induced diabetic cardiomyopathy by preventing the degenerative changes in the cardiomyocytes and the associated fibrosis, inflammation and decreased vasculature at structural and molecular levels.
Competing Interests: Declaration of Competing Interest No interesting conflict about this study.
(Copyright © 2020 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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