Bone Mineral Density in Relation to Chronic Kidney Disease After Heart Transplantation: A Retrospective Single-center Study at Skåne University Hospital in Lund 1988-2016.

Autor:	Löfdahl E; Department of Clinical Sciences Lund, Cardiology, Lund University, Lund, Sweden.; The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Skåne University Hospital, Lund, Sweden., Haggård C; Department of Clinical Sciences Lund, Cardiology, Lund University, Lund, Sweden.; The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Skåne University Hospital, Lund, Sweden., Rådegran G; Department of Clinical Sciences Lund, Cardiology, Lund University, Lund, Sweden.; The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Skåne University Hospital, Lund, Sweden.
Jazyk:	angličtina
Zdroj:	Transplantation direct [Transplant Direct] 2020 Feb 24; Vol. 6 (3), pp. e537. Date of Electronic Publication: 2020 Feb 24 (Print Publication: 2020).
DOI:	10.1097/TXD.0000000000000981
Abstrakt:	Background: Our aim was to investigate the bone mineral density (BMD) evolution and incidence of osteoporosis in relation to chronic kidney disease (CKD) up to 10 years after heart transplantation (HT). Methods: A retrospective analysis was performed on 159 HT patients at Skåne University Hospital in Lund 1988-2016. Results: The median follow-up time was 6.1 years (interquartile range = 7.5 y). HT patients with CKD stage <3 or normal kidney function before HT exhibited a greater mean BMD loss in the lumbar spine, compared to patients with CKD stage ≥3 before HT, at the first (-6.6% versus -2.5%, P = 0.029), second (-3.7% versus 2.1%, P = 0.018), and third (-2.0% versus 4.1%, P = 0.047) postoperative years, respectively. All included HT patients exhibited a BMD loss in the femoral neck at the first postoperative year (-8.8% [-10.3 to -7.3] in patients with CKD stage <3 or normal kidney function and -9.3% [-13.2 to -5.5] in patients with CKD stage ≥3 before HT), which was not fully reversed up to 10 years after HT. In adjusted models, CKD stage <3 before HT did not predict osteopenia and osteoporosis in the lumbar spine or femoral neck. Conclusions: CKD before HT did not predict BMD loss or osteoporosis development after HT. The study is, however, limited by a lack of data on fractures, and further studies on the relationship between CKD and postoperative bone strength are encouraged. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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