| Autor: |
Siqueira LG; Embrapa Gado de Leite, Juiz de Fora, MG, Brazil 36038-330; and Corresponding author. Email: luiz.siqueira@embrapa.br., Silva MVG; Embrapa Gado de Leite, Juiz de Fora, MG, Brazil 36038-330., Panetto JC; Embrapa Gado de Leite, Juiz de Fora, MG, Brazil 36038-330., Viana JH; Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil 70770-917. |
| Jazyk: |
angličtina |
| Zdroj: |
Reproduction, fertility, and development [Reprod Fertil Dev] 2019 Jan; Vol. 32 (2), pp. 82-97. |
| DOI: |
10.1071/RD19278 |
| Abstrakt: |
Abnormal fetuses, neonates and adult offspring derived by assisted reproductive technologies (ART) have been reported in humans, rodents and domestic animals. The use of ART has also been associated with an increased likelihood of certain adult diseases. These abnormalities may arise as a result of an excess of or missing maternally derived molecules during invitro culture, because the invitro environment is artificial and suboptimal for embryo development. Nonetheless, the success of ART in overcoming infertility or improving livestock genetics is undeniable. Limitations of invitro embryo production (IVEP) in cattle include lower rates of the establishment and maintenance of pregnancy and an increased incidence of neonatal morbidity and mortality. Moreover, recent studies demonstrated long-term effects of IVEP in cattle, including increased postnatal mortality, altered growth and a slight reduction in the performance of adult dairy cows. This review addresses the effects of an altered preimplantation environment on embryo and fetal programming and offspring development. We discuss cellular and molecular responses of the embryo to the maternal environment, how ART may disturb programming, the possible role of epigenetic effects as a mechanism for altered phenotypes and long-term effects of ART that manifest in postnatal life. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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