Multicenter Cross-sectional Study of Patients with Rheumatoid Arthritis in Greece: Results from a cohort of 2.491 patients.

Autor:	Thomas K; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Lazarini A; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Kaltsonoudis E; Rheumatology Clinic, University of Ioannina, Ioannina, Greece., Drosos A; Rheumatology Clinic, University of Ioannina, Ioannina, Greece., Papalopoulos I; Clinical Immunology and Allergy Department, University of Crete, Heraklion, Greece., Sidiropoulos P; Clinical Immunology and Allergy Department, University of Crete, Heraklion, Greece., Katsimbri P; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Boumpas D; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Tsatsani P; Rheumatology Unit, KAT Hospital, Athens, Greece., Gazi S; Rheumatology Unit, KAT Hospital, Athens, Greece., Fragkiadaki K; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Tektonidou M; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Sfikakis PP; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Pantazi L; Rheumatology Unit, Sismanoglio Hospital, Athens, Greece., Boki KA; Rheumatology Unit, Sismanoglio Hospital, Athens, Greece., Grika EP; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Vlachoyiannopoulos PG; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Karagianni K; Department of Rheumatology, University of Thessaly, Larissa, Greece., Sakkas LI; Department of Rheumatology, University of Thessaly, Larissa, Greece., Dimitroulas T; 4 Department of Medicine, Aristotle University, Thessaloniki, Greece., Garyfallos A; 4 Department of Medicine, Aristotle University, Thessaloniki, Greece., Kassimos D; 401 General Military Hospital, Athens, Greece., Evangelatos G; Rheumatology Unit, NIMTS Hospital, Athens, Greece., Iliopoulos A; Rheumatology Unit, NIMTS Hospital, Athens, Greece., Areti M; Private Practice, Greece., Georganas C; Private Practice, Greece., Melissaropoulos K; Rheumatology Unit, Agios Andreas Hospital, Patras, Greece., Georgiou P; Rheumatology Unit, Agios Andreas Hospital, Patras, Greece., Vounotrypidis P; Private Practice, Greece., Ntelis K; Private Practice, Greece., Mavragani CP; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Bournazos I; Private Practice, Greece., Katsifis G; Rheumatology Unit, Navy Hospital, Athens, Greece., Mavrommatis C; Private Practice, Greece., Kitas GD; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.; Hygeia Hospital, Athens, Greece., Vassilopoulos D; Joint Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Mediterranean journal of rheumatology [Mediterr J Rheumatol] 2018 Mar 19; Vol. 29 (1), pp. 27-37. Date of Electronic Publication: 2018 Mar 19 (Print Publication: 2018).
DOI:	10.31138/mjr.29.1.27
Abstrakt:	Aim of the Study: To evaluate the current disease characteristics, treatment and comorbidities of rheumatoid arthritis (RA) in Greece. Methods: Multicenter, cross-sectional study with a 9-month recruitment period between 2015 and 2016. Demographics, disease characteristics, treatment and comorbidities were collected via a web-based platform. Results: 2.491 RA patients were recruited: 96% from tertiary referral centers, 79% were females with a mean age of 63.1 years and disease duration of 9.9 years. Fifty-two percent were rheumatoid factor and/or anti-CCP positive, while 41% had erosive disease. Regarding treatment, 82% were on conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), 42% on biologic DMARDs (TNFi: 22%, non-TNFi: 20%) and 40% on corticosteroids (mean daily dose: 5.2 mg). Despite therapy, 36% of patients had moderate and 12% high disease activity. The most frequent comorbidities were hypertension (42%), hyperlipidemia (33%), osteoporosis (29%), diabetes mellitus (15%) and depression (12%). Latent tuberculosis infection (positive tuberculin skin test or interferon gamma release assay) was diagnosed in 13 and 15.3% of patients, respectively. Regarding chronic viral infections, 6.2% had history of herpes zoster while 2% and 0.7% had chronic hepatitis B and C virus infection, respectively. A history of serious infection was documented in 9.6%. Only 36% and 52% of the participants had ever been vaccinated against pneumococcus and influenza virus, respectively. Conclusion: This is one of the largest epidemiologic studies providing valuable data regarding the current RA characteristics in Greece. Half of patients were seropositive but despite therapy, half displayed residual disease activity, while preventive vaccination was limited. (© 2018 The Mediterranean Journal of Rheumatology (MJR).)
Databáze:	MEDLINE
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