Reviewing Mimosoideae lectins: A group of under explored legume lectins.

Autor: Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: bscavada@ufc.br., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Oliveira MV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Pinto-Junior VR; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Silva MTL; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Bari AU; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lima LD; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2020 Jul 01; Vol. 154, pp. 159-165. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1016/j.ijbiomac.2020.03.113
Abstrakt: Lectins are proteins capable of specific and reversible binding to mono- and/or oligosaccharides, and within this group, Legume lectins are the most studied. However, most of these studies focus on the Papilionoideae subfamily, with Caesalpinioideae and Mimosoideae lectins being significantly less explored in the literature. The Mimosoideae subfamily consists of at least 79 genera and 3275 species, but, to date, only about 14 lectins have been purified, a fact which shows the lack of studies for this group. Based on their purification protocols, as well as physicochemical and structural properties, Mimosoideae lectins are very heterogeneous. Despite the few studies, a wide variety of biological activities have been tested, including, for example, inflammatory, anticancer, antibacterial, and antifungal. In this context, the present review aims to summarize the available data regarding the purification, physicochemical and structural properties, as well as biological activities, of lectins extracted from plants of the Mimosoideae subfamily in order to bring more insight to researchers interested in further exploring the potential of these molecules.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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