Successful Management of l-Asparaginase-Associated Pancreatitis With Octreotide and Pegylated Asparaginase in 2 Patients With Acute Lymphoblastic Leukemia: Is There a Different Rare Warning Sign of Hypoglycemia for l-Asparaginase-Associated Pancreatitis?

Autor: Aydin Köker S; Division of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Oymak Y; Division of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Demirağ B; Division of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Karapinar TH; Division of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Koker A; Dokuz Eylul University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Intensive Care, Izmir, Turkey. Electronic address: kokeralper@gmail.com., Genç S; Division of Radiology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Erdemir G; Division of Pediatric Gastroenterology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey., Vergin RC; Division of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.
Jazyk: angličtina
Zdroj: Clinical therapeutics [Clin Ther] 2020 Apr; Vol. 42 (4), pp. e82-e86. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1016/j.clinthera.2020.02.015
Abstrakt: l-Asparaginase (l-Asp) is a critical component of chemotherapy for acute lymphoblastic leukemia (ALL). However, toxic effects associated with l-Asp, such as hepatic dysfunction, pancreatitis, hypercholesterolemia, and hyperglycemia, have occurred. In addition, acute pancreatitis is a significant life-threatening adverse event associated with ALL. We describe 2 patients with ALL who had l-Asp-associated pancreatitis (AAP), with one patient presenting with hyperglycemia and the other presenting with hypoglycemia during induction treatment. When octreotide was administered to both of these patients, the clinical findings and laboratory data were improved. AAP was not repeated after treatment with pegylated asparaginase. Although AAP has a high risk of mortality and morbidity in childhood, APP treatment with appropriate agents, such as octreotide, can be successful.
Competing Interests: Disclosures The authors have indicated that they have no conflicts of interest regarding the content of this article.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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