Development and Evaluation of Orodispersible Tablets Containing Ketoprofen.

Autor: Oliveira LJ; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., Veiga A; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., Stofella NCF; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., Cunha AC; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., da Graça T Toledo M; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., Andreazza IF; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil., Murakami FS; Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do Parana, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Current drug delivery [Curr Drug Deliv] 2020; Vol. 17 (4), pp. 348-360.
DOI: 10.2174/1567201817666200317122807
Abstrakt: Background: Orodispersible Tablets (ODTs) are an option to facilitate the intake of pharmaceutical solid dosage forms, which dissolve in the mouth within 30 seconds releasing the drug immediately with no need for water intake or chewing.
Objective: The main goal of our study is the technological development of lactose-free orodispersible tablets that contain ketoprofen.
Methods: We assessed different variables during the pharmaceutical development of ODTs: compression techniques conducted after a wet granulation process, aiming to optimize the flow properties of the formulation, and a suspension freeze-drying molded in blisters. We developed three formulations for each method, each containing one of the superdisintegrants: croscarmellose, crospovidone, or starch glycolate.
Results: During the production of ODTs, we performed quality control of the granulation process, since the production of pellets contributed to the enhancement of the disintegration time and content homogeneity. Quality control tests for ODTs produced by freeze-drying were also satisfactory, despite significant changes in the final physical aspect of these products when compared to that of ODTs produced by compression. In addition, the disintegration times of ODTs produced by freeze-drying were substantially higher. Furthermore, these tablets displayed greater friability and pose a challenge to the control of a standard individual weight.
Conclusion: Among the superdisintegrants, croscarmellose contributed most significantly to reduce the disintegration time and to dissolve KTP effectively in 20 minutes.
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Databáze: MEDLINE