Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents.

Autor:	Lee H; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Shahrivarkevishahi A; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Lumata JL; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Luzuriaga MA; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Hagge LM; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Benjamin CE; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Brohlin OR; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Parish CR; Department of Physics , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA., Firouzi HR; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Nielsen SO; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith., Lumata LL; Department of Physics , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA., Gassensmith JJ; Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email: gassensmith@utdallas.edu ; www.twitter.com/gassensmith.; Department of Bioengineering , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA.
Jazyk:	angličtina
Zdroj:	Chemical science [Chem Sci] 2020 Feb 05; Vol. 11 (8), pp. 2045-2050. Date of Electronic Publication: 2020 Feb 05 (Print Publication: 2020).
DOI:	10.1039/c9sc05510j
Abstrakt:	Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo . We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus. (This journal is © The Royal Society of Chemistry 2020.)
Databáze:	MEDLINE
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