Angiotensin receptor blockade with Losartan attenuates pressor response to handgrip contraction and enhances natriuresis in salt loaded hypertensive subjects: a quasi-experimental study among Nigerian adults.
| Autor: | Agbaraolorunpo FM; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Sofola OA; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Anigbogu CN; Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria., Azinge EC; Department of Clinical Pathology, College of Medicine, University of Lagos, Lagos, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2019 Dec 09; Vol. 34, pp. 188. Date of Electronic Publication: 2019 Dec 09 (Print Publication: 2019). |
| DOI: | 10.11604/pamj.2019.34.188.18317 |
| Abstrakt: | Introduction: Sympathetic and Renin-Angiotensin-Aldosterone systems play crucial roles in blood pressure response to increased salt intake. This study investigated the effects of angiotensin receptor blocker (ARB) and sympathetic excitation on the responses of blood pressure (BP) and peripheral vascular resistance (PVR) in salt loaded normotensive (NT) and hypertensive (HT) Nigerian subjects. Methods: 16 NT and 14 HT participants, that were age-matched [39.9 ± 1.3 vs 44.1±2.1yrs (P= 0.10)], underwent 5 days each of oral administration of 200mmol NaCl, and 200mmol NaCl + 50mg Losartan, preceded by a baseline control condition. BP and PVR responses to 30% Maximum Voluntary Contraction (MVC) of handgrip (HG) for one minute were determined at baseline, after salt load and after salt + Losartan. Data were presented as Mean ± SEM, and analyzed with two-way ANOVA and paired t-test, with P<0.05 accepted as significant. Results: BP and PVR were significantly increased by HG at baseline, after salt load and after salt + Losartan in NT and HT. Salt load augmented the HG-induced SBP (P=0.04) and MABP responses (P=0.02) in HT. While Losartan attenuated the HG- induced Systolic Blood Pressure (SBP) SBP response (P=0.007) and DBP response (P=0.003) in HT and NT respectively after salt + Losartan. HG-induced PVR response was significantly accentuated after salt load in HT (P=0.005), but it was not significant in NT (P=0.38). Conclusion: The implication of our finding is that angiotensin II receptor blockade possibly attenuates salt-induced sympathetic nerve excitation in black hypertensive patients. Competing Interests: The authors declare no competing interests. (© Francis Muyiwa Agbaraolorunpo et al.) |
| Databáze: | MEDLINE |
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