Coriandrum sativum Extract Prevents Alarm Substance-Induced Fear- and Anxiety-Like Responses in Adult Zebrafish.

Autor:	Zenki KC; Laboratory of Cellular Neurochemistry, Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratory of Neuropharmacological Studies in Zebrafish, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil., Souza LS; Laboratory of Neuropharmacological Studies in Zebrafish, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil., Góis AM; Laboratory of Neuropharmacological Studies in Zebrafish, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil., Lima BDS; Laboratory of Pharmaceutical Trials and Toxicity, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil., Araújo AAS; Laboratory of Pharmaceutical Trials and Toxicity, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil., Vieira JS; Laboratory of Nutrition of Aquatic Organisms, Department of Zootechny, Universidade Federal de Sergipe, São Cristóvão, Brazil., Camargo EA; Laboratory of Pharmacology of Natural Products and Inflammation, Department of Physiology, Universidade Federal de Sergipe, São Cristóvão, Brazil., Kalinine E; Laboratory of Cellular Neurochemistry, Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratory of Pharmacology of Natural Products and Inflammation, Department of Physiology, Universidade Federal de Sergipe, São Cristóvão, Brazil., Oliveira DL; Laboratory of Cellular Neurochemistry, Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Walker CIB; Laboratory of Cellular Neurochemistry, Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Laboratory of Neuropharmacological Studies in Zebrafish, Department of Pharmacy, Universidade Federal de Sergipe, São Cristóvão, Brazil.
Jazyk:	angličtina
Zdroj:	Zebrafish [Zebrafish] 2020 Apr; Vol. 17 (2), pp. 120-130. Date of Electronic Publication: 2020 Mar 16.
DOI:	10.1089/zeb.2019.1805
Abstrakt:	Anxiety disorders appear to involve distinct neurobiological mechanisms and several medications are available against this mental health problem. However, pharmacological therapeutic approaches display undesirable side effects for patients, particularly when long-term therapy is required. Some evidences have suggested that Coriandrum sativum extract (CSE) provide sedative and anxiolytic effects. We investigate if CSE could attenuate anxiety-like behaviors induced by novelty and alarm substance exposures in zebrafish. Adult zebrafish were injected with vehicle, clonazepam, or CSE (25, 50 or 100 mg/kg) and submitted to novel tank test. At the end, saline or alarm substance was added and anxiety-like responses were recorded. Twenty-four hours after, fish were submitted to the light/dark test. Novelty associated with alarm substance exposure decreased distance traveled and total time mobile in novel tank, and CSE (at 50 and 100 mg/kg) prevented these alterations similarly to clonazepam. Alarm substance reduced the time spent in white compartment ( p  = 0.0193 as compared with vehicle group). Clonazepam and CSE prevented this anxiogenic effect of alarm substance. CSE presents anxiolytic effects against alarm substance-induced locomotor and anxiogenic responses similarly to clonazepam. These data corroborate with the use of this plant in traditional medicine and provides a putative new pharmacological intervention for anxiety disorders.
Databáze:	MEDLINE
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