Electrochemical methods to enhance osseointegrated prostheses.

Autor: Ehrensberger MT; 1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.; 2Department of Orthopaedics, University at Buffalo, Buffalo, NY USA., Clark CM; 1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA., Canty MK; 1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.; 3Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY USA., McDermott EP; 1Department of Biomedical Engineering, University at Buffalo, 445 Biomedical Research Building, 3435 Main Street, Buffalo, NY 14214 USA.
Jazyk: angličtina
Zdroj: Biomedical engineering letters [Biomed Eng Lett] 2019 Nov 19; Vol. 10 (1), pp. 17-41. Date of Electronic Publication: 2019 Nov 19 (Print Publication: 2020).
DOI: 10.1007/s13534-019-00134-8
Abstrakt: Osseointegrated (OI) prosthetic limbs have been shown to provide an advantageous treatment option for amputees. In order for the OI prosthesis to be successful, the titanium implant must rapidly achieve and maintain proper integration with the bone tissue and remain free of infection. Electrochemical methods can be utilized to control and/or monitor the interfacial microenvironment where the titanium implant interacts with the biological system (host bone tissue or bacteria). This review will summarize the current understanding of how electrochemical modalities can influence bone tissue and bacteria with specific emphasis on applications where the metallic prosthesis itself can be utilized directly as a stimulating electrode for enhanced osseointegration and infection control. In addition, a summary of electrochemical impedance sensing techniques that could be used to potentially assess osseointegration and infection status of the metallic prosthesis is presented.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Korean Society of Medical and Biological Engineering 2019.)
Databáze: MEDLINE
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