A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations.

Autor: Ruddaraju LK; Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Bhimavaram 534202, India., Pammi SVN; Department of Materials Science and Engineering, Chungnam National University, Republic of Korea., Guntuku GS; A.U. College of Pharmaceutical Sciences, Visakhapatnam 530003, India., Padavala VS; Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Bhimavaram 534202, India., Kolapalli VRM; A.U. College of Pharmaceutical Sciences, Visakhapatnam 530003, India.
Jazyk: angličtina
Zdroj: Asian journal of pharmaceutical sciences [Asian J Pharm Sci] 2020 Jan; Vol. 15 (1), pp. 42-59. Date of Electronic Publication: 2019 Jun 12.
DOI: 10.1016/j.ajps.2019.03.002
Abstrakt: In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance. Subsequently, nanoparticles (NPs) were proposed to cease the multi-drug resistant bacteria but were hindered due to toxicity issues. Recently, a novel adjuvant therapy employed metals and botanicals into innovative nanotechnology as nano-antibiotics. The combination of green synthesized metallic NPs with antibiotics seems to be a viable platform to combat against MDR bacteria by alleviating resistance and toxicity. This review focuses on the primitive to present era dealings with bacterial resistance mechanisms, newer innovations of nanotechnology and their multiple mechanisms to combat resistance. In addition, special focus is paid on greener NPs as antibiotic carriers, and their future prospects of controlled release and toxicity study.
(© 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V.)
Databáze: MEDLINE
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