Paper Millifluidics Lab: Using a Library of Color Tests to Find Adulterated Antibiotics.
| Autor: | Bliese SL; Chemistry and Biochemistry Department, University of Notre Dame, Notre Dame, Indiana 46556, United States., O'Donnell D; Chemistry Department, Hamline University, St. Paul, Minnesota 55104, United States., Weaver AA; Civil & Environmental Engineering & Earth Sciences Department, University of Notre Dame, Notre Dame, Indiana 46556, United States., Lieberman M; Chemistry and Biochemistry Department, University of Notre Dame, Notre Dame, Indiana 46556, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of chemical education [J Chem Educ] 2020 Mar 10; Vol. 97 (3), pp. 786-792. Date of Electronic Publication: 2020 Feb 18. |
| DOI: | 10.1021/acs.jchemed.9b00433 |
| Abstrakt: | A two to three period analytical chemistry experiment has been developed which allows second year students to explore chemical color tests used to detect adulterated pharmaceuticals. Students prepare several paper analytical devices (PADs) to generate positive and negative controls antibiotics, along with cutting agents such as starch and chalk. These PADs are used to identify the active ingredients and excipients in mystery tablets prepared by their classmates. In the second part of the lab, the students select an individual color test and design an experiment to quantify their mystery pill's active pharmaceutical ingredient (API). Nearly all of the student groups were able to successfully identify adulterants present in their mystery tablets. The quantification of the mystery tablets was also successful with all but one group calculating the correct concentration within 6%. In a postlab assessment, the students identified their largest gains in their ability to analyze data and other information, skill in science writing, and learning of laboratory techniques. Competing Interests: The authors declare the following competing financial interest(s): One author, M.L., holds a patent (US 009354181B2) on the paper analytical devices (PADs) used in this study. Licensing negotiations for this patent with a U.S. company are underway. The U.S. patent will not prevent others from manufacturing or selling PADs. (Copyright © 2020 American Chemical Society and Division of Chemical Education, Inc.) |
| Databáze: | MEDLINE |
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