Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers.

Autor: Mishima G; Division of Clinical Physiology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan., Sanuki T; Division of Clinical Physiology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan., Revie J; Fisher & Paykel Healthcare Ltd, Auckland, New Zealand., Pinkham M; Fisher & Paykel Healthcare Ltd, Auckland, New Zealand., Watanabe T; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan., Kurata S; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan., Tatkov S; Fisher & Paykel Healthcare Ltd, Auckland, New Zealand., Ayuse T; Division of Clinical Physiology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan. Electronic address: ayuse@nagasaki-u.ac.jp.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2020 Jun; Vol. 277, pp. 103429. Date of Electronic Publication: 2020 Mar 12.
DOI: 10.1016/j.resp.2020.103429
Abstrakt: Objective: Hypoventilation and carbon dioxide (CO 2 ) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol.
Methods: NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO 2 (TcCO 2 ), and SpO 2 .
Results: During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO 2 by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO 2 and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively.
Conclusion: During sedation with propofol, NHF without supplemental oxygen attenuated CO 2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.
Competing Interests: Declaration of Competing Interest J. R., M. P., and S. T. are employees of Fisher & Paykel Healthcare Ltd, the manufacturers of the nasal high flow (NHF) devices used in the study. T. A. has received funding and support from Fisher & Paykel Healthcare Ltd. G. M., T. S., T. W., and S. K. have no declaration of interest.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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