Effects of gender on cognitive and behavioral manifestations in multiple system atrophy.

Autor: Cuoco S; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'ScuolaMedicaSalernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy., Picillo M; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'ScuolaMedicaSalernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy., Cappiello A; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Carotenuto I; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Erro R; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'ScuolaMedicaSalernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy., Russillo MC; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Abate F; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Volpe G; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Squillante M; Neurology, Scuola Medica Salernitana, University Hospital A.O.U. OO.RR. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Cozzolino A; Neurology Unit, S.G. Moscati Hospital, Avellino, Italy., Cicarelli G; Neurology Unit, S.G. Moscati Hospital, Avellino, Italy., Santangelo G; Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy., Barone P; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'ScuolaMedicaSalernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy., Pellecchia MT; Neuroscience Section, Department of Medicine, Surgery and Dentistry 'ScuolaMedicaSalernitana', Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. mpellecchia@unisa.it.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2020 Jun; Vol. 127 (6), pp. 925-934. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1007/s00702-020-02169-z
Abstrakt: Gender differences have been described in several neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The effects of gender on cognitive and behavioral manifestations in multiple system atrophy and the changes of cognitive functions over time according to gender have not been investigated so far. Fifty-five patients with a diagnosis of multiple system atrophy underwent a comprehensive neuropsychological and neuropsychiatric battery at baseline and 26 of them could be re-evaluated at 1-year follow-up. At baseline women with multiple system atrophy had poorer global cognitive state and visuo-spatial abilities, and a higher prevalence of depression and apathy than males. At follow-up, female patients deteriorated more than males on attention abilities and motor functions, and had a higher prevalence of depression than men. Executive functions and visuo-spatial abilities significantly worsened over time in both groups. Mild Cognitive Impairment single domain was significantly more frequent in females than males. Cognitive and behavioral differences between genders in multiple system atrophy involve global cognition, planning, attention, visual-perceptive skills, and depression, with female patients more compromised than males. Female patients deteriorated more than men over time as for motor functions and attention. Further longitudinal studies are deserved to confirm gender differences in progression of cognitive and behavioral features of multiple system atrophy.
Databáze: MEDLINE
Externí odkaz: