An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity.

Autor: de Sousa AP; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil., Gondim ACS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil., Sousa EHS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil., de Vasconcelos MA; Laboratório Integrado de Biomoléculas, Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE, 60430-270, Brazil.; Departamento de Ciências Biológicas, Faculdade de Ciências Exatas e Naturais, Universidade do Estado do Rio Grande do Norte, Mossoró, RN, 59625-620, Brazil., Teixeira EH; Laboratório Integrado de Biomoléculas, Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE, 60430-270, Brazil., Bezerra BP; Departmento de Física, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Ayala AP; Departmento de Física, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Martins PHR; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil., Lopes LGF; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil., Holanda AKM; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici s/n, Cx. Postal 12200, Fortaleza, CE, 60440-900, Brazil. aldakarine@dqoi.ufc.br.
Jazyk: angličtina
Zdroj: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2020 May; Vol. 25 (3), pp. 419-428. Date of Electronic Publication: 2020 Mar 14.
DOI: 10.1007/s00775-020-01772-5
Abstrakt: The cis-[Ru(bpy) 2 (Met)](PF 6 ) 2 complex, where Met = L-methionine and bpy = 2,2'-bipyridine, was prepared and fully characterized. This complex was subjected to blue and green light photolysis (453 and 505 nm, respectively) in aqueous solution, leading to the release of methionine and formation of the cis-[Ru(bpy) 2 (H 2 O) 2 ] 2+ ion. This latter photoproduct was shown to subsequently interact with DNA, while DNA photocleavage was noticed. In agreement with these reactivities, this compound exhibited an exciting antibacterial action, particularly against Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, which was enhanced upon blue light irradiation. Altogether, these results showed that our strategy was successful in producing light-triggered DNA-binding agents with pharmacological potential and a likely blocking reagent for efficient peptide chemistry formation.
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje