Immune cell engineering: opportunities in lung cancer therapeutics.

Autor: Bhargava A; Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India., Mishra DK; Indore Institute of Pharmacy, Indore, India., Tiwari R; Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India., Lohiya NK; School of Life Sciences, University of Rajasthan, Jaipur, India., Goryacheva IY; Department of General and Inorganic Chemistry, Saratov State University, Saratov, Russian Federation., Mishra PK; Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Kamla Nehru Hospital,, Building (Gandhi Medical College Campus), Bhopal, Madhya Pradesh, 462001, India. pkm_8bh@yahoo.co.uk.
Jazyk: angličtina
Zdroj: Drug delivery and translational research [Drug Deliv Transl Res] 2020 Oct; Vol. 10 (5), pp. 1203-1227.
DOI: 10.1007/s13346-020-00719-2
Abstrakt: Engineered immune cells offer a prime therapeutic alternate for some aggressive and frequently occurring malignancies like lung cancer. These therapies were reported to result in tumor regression and overall improvement in patient survival. However, studies also suggest that the presence of cancer cell-induced immune-suppressive microenvironment, off-target toxicity, and difficulty in concurrent imaging are some prime impendent in the success of these approaches. The present article reviews the need and significance of the currently available immune cell-based strategies for lung cancer therapeutics. It also showcases the utility of incorporating nanoengineered strategies and details the available formulations of nanocarriers. In last, it briefly discussed the existing methods for nanoparticle fuctionalization and challenges in translating basic research to the clinics. Graphical Abstract.
Databáze: MEDLINE
Externí odkaz: