Diphenyl diselenide dietary supplementation protects against fumonisin B 1 -induced oxidative stress in brains of the silver catfish Rhamdia quelen.

Autor: Baldissera MD; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Souza CF; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., da Silva HNP; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Zeppenfeld CC; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Dornelles JL; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Henn AS; Department of Chemistry, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Duarte FA; Department of Chemistry, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., da Costa ST; Department of Morphology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Da Silva AS; Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil., Cunha MA; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Baldisserotto B; Department of Physiology and Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address: bernardo@smail.ufsm.br.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2020 May; Vol. 231, pp. 108738. Date of Electronic Publication: 2020 Mar 10.
DOI: 10.1016/j.cbpc.2020.108738
Abstrakt: The trend toward using plant-based ingredients in aquafeeds has raised important concerns for aquaculture owing to the negative impacts of mycotoxins on fish health; with emphasis for contamination by fumonisin B 1 (FB 1 ). The brain is an important target of FB 1 ; however, study of the pathways linked to brain damage is limited to an analysis of histopathological alterations. Reports have demonstrated the protective effects of dietary supplementation with diphenyl diselenide (Ph 2 Se 2 ) in the brains of fish subjected to several environmental insults; nevertheless, its neuroprotective effects in fish fed with diets contaminated with FB 1 remain unknown. Therefore, the aim of this study was to evaluate whether oxidative damage may be a pathway associated with FB 1 -induced neurotoxicity, as well as to evaluate whether dietary supplementation with Ph 2 Se 2 prevents or reduces FB 1 -mediated brain oxidative damage in silver catfish. Brain reactive oxygen species (ROS), lipid peroxidation (LOOH) and protein carbonylation increased on day 30 post-feeding in animals that received FB 1 -contaminated diets compared to the control group, while brain antioxidant capacity against peroxyl radicals (ACAP) levels and catalase (CAT), glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities were lower. Diphenyl diselenide dietary supplementation avoid increases in brain ROS levels, as well minimizing the augmentation of LOOH levels. Furthermore, Ph 2 Se 2 prevented impairment of brain ACAP levels, as well as GPx and GST activities elicited by FB 1 -contaminated diets. These data suggest that dietary supplementation with 3 mg/kg Ph 2 Se 2 prevented FB 1 -induced brain damage in silver catfish, and this protective effect occurred through avoided of excessive ROS production, as well as via prevention of brain lipid damage. Furthermore, Ph 2 Se 2 exerted its neuroprotective effects via ameliorative effects on the enzymatic and non-enzymatic antioxidant defense systems, and may be an approach to prevent FB 1 -induced brain oxidative stress; however, is not an alternative to prevent the impairment on performance caused by FB 1 .
Competing Interests: Declaration of competing interest None.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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