Prevalence and risk factors for gallstone disease: A population-based cross-sectional study.

Autor: Song ST; Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China., Shi J; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China., Wang XH; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China., Guo YB; Department of Health Statistics, Second Military Medical University, Shanghai, China., Hu PF; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China., Zhu F; Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China., Zeng X; Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China., Xie WF; Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Jazyk: angličtina
Zdroj: Journal of digestive diseases [J Dig Dis] 2020 Apr; Vol. 21 (4), pp. 237-245. Date of Electronic Publication: 2020 Apr 15.
DOI: 10.1111/1751-2980.12857
Abstrakt: Objective: To explore the prevalence of and risk factors for gallstone disease in Shanghai, China.
Methods: A population-based cross-sectional study was conducted in Shanghai between 2016 and 2017. Using a three-stage stratified sampling strategy, 4009 participants (1753 men and 2256 women) from 10 districts were enrolled.
Results: The overall prevalence of gallstones was 6.83% (6.22% for men vs 7.31% for women, P = 0.173). According to the multivariate analysis, individuals aged ≥40 years (odds ratio [OR] 3.058, 95% confidence interval [CI] 2.110-4.433, P < 0.001), hypertension (OR 1.479, 95% CI 1.076-2.034, P = 0.016), thyroid disease (OR 1.409, 95% CI 1.029-1.928, P = 0.032), a family history of gallstones (OR 2.234, 95% CI 1.362-3.662, P = 0.001) and a waist-to-height ratio ≥0.5 (OR 1.656, 95% CI 1.197-2.292, P = 0.002) had an increased risk of developing gallstones. The risk of gallstone disease was 2.232 (95% CI 1.167-4.268, P = 0.015) times higher in individuals with elevated C4 levels than in those with normal C4 levels. Diabetes (OR 4.144, 95% CI 1.171-14.671, P = 0.028) was a risk factor for the formation of gallstones with diameters ≥1 cm, and men were more susceptible to develop multiple stones (OR 2.356, 95% CI 1.321-4.200, P = 0.004).
Conclusion: Individuals aged ≥40 years, with a history of hypertension and familial gallstones, a high waist-to-height ratio, thyroid disease and high C4 levels were related to an increased risk of gallstone disease.
(© 2020 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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