Advances and challenges in nanocarriers and nanomedicines for veterinary application.

Autor: Carvalho SG; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil. Electronic address: suzana2994@gmail.com., Araujo VHS; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil., Dos Santos AM; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil., Duarte JL; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil., Silvestre ALP; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil., Fonseca-Santos B; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), 13083-871 Campinas, SP, Brazil., Villanova JCO; Laboratory of Pharmaceutical Production, Departament of Pharmacy and Nutrition - Federal University of Espirito Santo (UFES), 29500-000 Alegre, ES, Brazil., Gremião MPD; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil., Chorilli M; Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2020 Apr 30; Vol. 580, pp. 119214. Date of Electronic Publication: 2020 Mar 09.
DOI: 10.1016/j.ijpharm.2020.119214
Abstrakt: To ensure success in the development and manufacturing of nanomedicines requires forces of an interdisciplinary team that combines medicine, engineering, chemistry, biology, material and pharmaceutical areas. Numerous researches in nanotechnology applied to human health are available in the literature. Althought, the lack of nanotechnology-based pharmaceuticals products for use exclusively in veterinary pharmacotherapy creates a potential area for the development of innovative products, as these animal health studies are still scarce when compared to studies in human pharmacotherapy. Nano-dosage forms can ensure safer and more effective pharmacotherapy for animals and can more be safer for the consumers of livestock products, once they can offer higher selectivity and smaller toxicity associated with lower doses of the drugs. In addition, the development and production of nanomedicines may consolidate the presence of pharmaceutical laboratories in the global market and can generate greater profit in a competitive business environment. To contribute to this scenario, this article provides a review of the main nanocarriers used in nanomedicines for veterinary use, with emphasis on liposomes, nanoemulsions, micelles, lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, metallic nanoparticles and dendrimers, and the state of the art of application of these nanocarriers in drug delivery systems to animal use. Finnaly, the major challenges involved in research, scale-up studies, large-scale manufacture, analytical methods for quality assessment, and regulatory aspects of nanomedicines were discussed.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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