Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid.

Autor: Graminha AE; Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil; Departamento de Gerontologia, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil. Electronic address: aegraminha@gmail.com., Honorato J; Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil., Dulcey LL; Departamento de Gerontologia, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil., Godoy LR; Departamento de Gerontologia, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil., Barbosa MF; Instituto de Química, Universidade Federal de Alfenas, 37130-000 Alfenas, MG, Brazil., Cominetti MR; Departamento de Gerontologia, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil., Menezes AC; Centro de Ciências Exatas e Tecnologia, Universidade Estadual de Goiás, CEP 75132-903 Anápolis, GO, Brazil., Batista AA; Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil. Electronic address: daab@ufscar.br.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2020 May; Vol. 206, pp. 111021. Date of Electronic Publication: 2020 Feb 14.
DOI: 10.1016/j.jinorgbio.2020.111021
Abstrakt: In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF 6 , where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor cells from the lines MCF-7, MDA-MB-231 and in human (MCF-10A) or mouse (L929) non-tumor cells. Complexes Ru(L 4 )(dppb)(bipy)]PF 6 (4) (L 4  = 4-hydroxycinnamic acid) and [Ru(L 5 )(dppb)(bipy)]PF 6 (5) (L 5  = 3,4-dihydroxycinnamic acid) were the most selective, presenting the highest values of selectivity indexes besides inhibited some processes related to tumor progression in vitro, such as invasion, migration, and adhesion in the MDA-MB-231 cell line. In addition, the complexes 4 and 5 were able to interact with Bovine Serum Albumin (BSA) and complex 5 showed antioxidant activity.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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