| Autor: |
Yin X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Qi J; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Li Y; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Bao Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Du P; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Kou R; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Wang W; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China., Gao JM; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China. |
| Abstrakt: |
Three new cyathane diterpenoids named stercorins A-C ( 1-3 ), including one with unusual 4,9- seco -carbon skeleton, together with two new drimane sesquiterpenoids named stercorins D ( 4 ) and E ( 5 ) were isolated from the liquid cultures of the basidiomycete Cyathus stercoreus . Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS. All three cyathane diterpenoids showed neurotrophic activity in PC-12 cells at concentrations of 10 µ M. Compounds 1-3 significantly suppressed LPS-induced NO production in culture medium in BV2 cells with the IC 50 values of 1.64 μ M, 9.25 μ M and 8.71 μ M, respectively. Notably, Compound 1 , possessing an uncommon medium-sized 9/7 ring system showed the most promising role in the prevention of two activities-associated neurodegenerative diseases. |
