Increased Risk of ADHD at Short and Long Interpregnancy Intervals in a National Birth Cohort.

Autor: Cheslack-Postava K; Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY., Sourander A; Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY.; Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., Suominen A; Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., Jokiranta-Olkoniemi E; Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., McKeague IW; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY., Brown AS; Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY.
Jazyk: angličtina
Zdroj: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2021 Jul; Vol. 35 (4), pp. 392-400. Date of Electronic Publication: 2020 Mar 12.
DOI: 10.1111/ppe.12657
Abstrakt: Background: Short or long interpregnancy interval (IPI) may adversely impact conditions for foetal development. Whether attention deficit hyperactivity disorder (ADHD) is related to IPI has been largely unexplored.
Objectives: To examine the association between IPI and ADHD in a large, population-based Finnish study.
Methods: All children born in Finland between 1991 and 2005 and diagnosed with ADHD (ICD-9 314x or ICD-10 F90.x) from 1995 to 2011 were identified using data from linked national registers. Each subject with ADHD was matched to 4 controls based on sex, date of birth, and place of birth. A total of 9564 subjects with ADHD and 34,479 matched controls were included in analyses. IPI was calculated as the time interval between sibling birth dates minus the gestational age of the second sibling. The association between IPI and ADHD was determined using conditional logistic regression and adjusted for potential confounders.
Results: Relative to births with an IPI of 24 to 59 months, those with the shortest IPI (<6 months) had an increased risk of ADHD (odds ratio [OR] 1.30, 95% confidence interval (CI) 1.12, 1.51) and the ORs for the longer IPI births (60-119 months and ≥120 months) were 1.12 (95% CI 1.02, 1.24) and 1.25 (95% CI 1.08, 1.45), respectively. The association of longer IPI with ADHD was attenuated by adjustment for maternal age at the preceding birth, and comorbid autism spectrum disorders did not explain the associations with ADHD.
Conclusions: The risk of ADHD is higher among children born following short or long IPIs although further studies are needed to explain this association.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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